Robert Rand Allingham, M.D.

Chief, Glaucoma Ophthalmology

Richard and Kit Barkhouser Professor of Ophthalmology

Department:
Ophthalmology

Division:
Glaucoma

Email:
allin002mcdukeedu

Mailing Address:
Box 3802, DUMC
Durham, NC 27710

Telephone:
919-684-2841

Training:
M.D., University of Cincinnati College of Medicine

Last Updated:
July 16, 2009

Clinical Interests:
Glaucoma (including laser and conventional surgery), cataract surgery withemphasis on combined cataract and glaucoma, and glaucoma implant surgery,research interests include new surgical approaches to glaucoma and the study ofgenetics in glaucoma and other inherited eye diseases

Research Interests:
Dr. Allingham has pursued both basic science and clinical research in the subspecialty of glaucoma.  His major research interest is the study of genetic eye disorders, primarily the inherited glaucomas.   The most common form of glaucoma (primary open-angle glaucoma or POAG) is believed to have a strong genetic component.  He leads a large NIH funded study of which is directed at identifying the specific gene(s) responsible for glaucoma.  Over 4,000 individuals have been enrolled in the Duke Glaucoma Genetics Project over the past 15 years. He has conducted studies of glaucoma worldwide including Iceland, Africa, Mexico, India, and the Philippines. Dr. Allingham's research group has identified the genetic location of several new genes associated with glaucoma. By understanding the genetic source of glaucoma it will be possible to develop new diagnostic and treatment approaches for this disease.    

In addition to basic science research efforts into the glaucomas, he has had an on-going interest in the clinical management of glaucoma.  They include 1) examination of various laser treatment modalities in glaucoma; 2) the tissue response to laser surgery; and 3) investigations into innovative surgical treatment strategies for glaucoma.

Publications:
2009 -- Pubmed # 19444463 -- Berdahl JP, Ethier CR, Allingham RR. Cerebrospinal fluid pressure and glaucomatous optic disc cupping. Graefes Arch Clin Exp Ophthalmol. 2009 May 15.

2009 -- Pubmed # 19061886 -- Allingham RR, Liu Y, Rhee DJ. The genetics of primary open-angle glaucoma: a review. Exp Eye Res. 2009 Apr;88(4):837-44.

2008 -- Pubmed # 18421074 -- Liu Y, Schmidt S, Qin X, Gibson J, Hutchins K, Santiago-Turla C, Wiggs JL, Budenz DL, Akafo S, Challa P, Herndon LW, Hauser MA, Allingham RR. Lack of association between LOXL1 variants and primary open-angle glaucoma in three different populations. Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3465-8.

2008 -- Pubmed # 19277240 -- Allingham RR. Assessment of visual status of the Aeta, a hunter-gatherer population of the Philippines (an AOS thesis). Trans Am Ophthalmol Soc. 2008;106:240-51.

2008 -- Pubmed # 19096531 -- Liu Y, Akafo S, Santiago-Turla C, Cohen CS, Larocque-Abramson KR, Qin X, Herndon LW, Challa P, Schmidt S, Hauser MA, Allingham RR. Optineurin coding variants in Ghanaian patients with primary open-angle glaucoma. Mol Vis. 2008;14:2367-72.

2006 -- Pubmed # 16971892 -- Challa P, Hauser MA, Luna CC, Freedman SF, Pericak-Vance M, Yang J, McDonald MT, Allingham RR. Juvenile bilateral lens dislocation and glaucoma associated with a novel mutation in the fibrillin 1 gene. Mol Vis. 2006;12:1009-15.

2005 -- Pubmed # 15914615 -- Allingham RR, Wiggs JL, Hauser ER, Larocque-Abramson KR, Santiago-Turla C, Broomer B, Del Bono EA, Graham FL, Haines JL, Pericak-Vance MA, Hauser MA. Early adult-onset POAG linked to 15q11-13 using ordered subset analysis. Invest Ophthalmol Vis Sci. 2005 Jun;46(6):2002-5.

2002 -- Pubmed # 12362081 -- Challa P, Herndon LW, Hauser MA, Broomer BW, Pericak-Vance MA, Ababio-Danso B, Allingham RR. Prevalence of myocilin mutations in adults with primary open-angle glaucoma in Ghana, West Africa. J Glaucoma. 2002 Oct;11(5):416-20.

2001 -- Pubmed # 11371492 -- Allingham RR, Loftsdottir M, Gottfredsdottir MS, Thorgeirsson E, Jonasson F, Sverisson T, Hodge WG, Damji KF, Stefánsson E. Pseudoexfoliation syndrome in Icelandic families. Br J Ophthalmol. 2001 Jun;85(6):702-7.

1998 -- Allingham RR, Wiggs JL, Damji KF, Herndon L, Youn J, Tallett DA, Jones KH, Del Bono EA, Reardon M, Haines JL, and Pericak-Vance MA. Adult-onset primary open-angle glaucoma does not localize to chromosome 2cen-q13 in north american families, Hum Heredity 48:251-255, 1998.

1996 -- Allingham RR, de Kater AW, Ethier CR: Schlemm's canal and primary open angle glaucoma: Correlation between Schlemm's canal dimensions and outflow facility. Experimental Eye Res, 62:101-109, 1996.

1990 -- Allingham RR, de Kater AW, Hsu J, Bellows AR: Probe placement and power levels in contact transscleral Nd:YAG cyclophotocoagulation. Arch. Ophthalmol, 108:738-742, 1990.

1988 -- Allingham, R.R.; Williams, P.B., Crouch, E.R., et. al.: Topical applied aminocaproic acid significantly reduces the incidence of secondary hemorrhage in traumatic hyphemia in the rabbit model. Arch Ophthalmol 106:1436-1438, 1988.