Hal Cecil Charles, Ph.D.

Associate Professor of Radiology

Department:
Radiology

Division:
Radiology - General

Email:
cecilcharlesdukeedu

Mailing Address:
Box 2702, DUMC
Durham, NC 27710

Telephone:
919-684-7350

Training:
Ph.D., University of North Carolina at Chapel Hill

Last Updated:
August 30, 2005

Research Interests:


Dr. Charles is an Associate Professor of Radiology, a chemist and an expert in MR imaging and spectroscopy with over 20 years of experience in nuclear magnetic resonance. He serves as the Co-Director of the Duke Center for Advanced Magnetic Resonance Development. He also has extensive experience in conducting imaging and spectroscopy studies. He has had extensive experience in conducting longitudinal clinical trials with MRI and MRS used as biomarkers. He was part of the first NIH sponsored clinical trial of MR in-vivo spectroscopy.Charles' research is in the general area of magnetic resonance spectroscopy and imaging.  Current projects involve metabolic imaging  in a variety of biomedical areas including tumor biology and therapy monitoring, pharmacodynamic evaluation in psychiatric disorders, biopsychiatric evaluation in depression,  social phobia, and Alzheimer's disease.  In addition, Dr. Charles pursues projects associated with the technology of MRS/I such asrf coil design, data reconstruction tactics, and in-vivo decoupling developments.  He is also director of the Duke Image Analysis Laboratory  which is active in conducting clinical trials in CNS disorders (schizophrenia, MCI, AD), cancer, and osteoarthritis using imaging based biomarkers.

Publications:
2002 -- Pubmed # 12113897 -- Kim DM, Xanthakos SA, Tupler LA, Barboriak DP, Charles HC, MacFall JR, Krishnan KR. MR signal intensity of gray matter/white matter contrast and intracranial fat: effects of age and sex. Psychiatry Res. 2002 Jul 1;114(3):149-61.

2002 -- Pubmed # 11884656 -- Chen JG, Edwards CL, Vidyarthi S, Pitchumoni S, Tabrizi S, Barboriak D, Charles HC, Doraiswamy PM. Learning and recall in subjects at genetic risk for Alzheimer's disease. J Neuropsychiatry Clin Neurosci. 2002 Winter;14(1):58-63.

2001 -- Pubmed # 11295375 -- Gilmore JH, van Tol JJ, Lewis Streicher H, Williamson K, Cohen SB, Greenwood RS, Charles HC, Kliewer MA, Whitt JK, Silva SG, Hertzberg BS, Chescheir NC. Outcome in children with fetal mild ventriculomegaly: a case series. Schizophr Res. 2001 Mar 30;48(2-3):219-26.

2001 -- Pubmed # 11527602 -- Gilmore JH, Gerig G, Specter B, Charles HC, Wilber JS, Hertzberg BS, Kliewer MA. Infant cerebral ventricle volume: a comparison of 3-D ultrasound and magnetic resonance imaging. Ultrasound Med Biol. 2001 Aug;27(8):1143-6.

2000 -- Pubmed # 10851380 -- Barboriak DP, Doraiswamy PM, Krishnan KR, Vidyarthi S, Sylvester J, Charles HC. Hippocampal sulcal cavities on MRI: relationship to age and apolipoprotein E genotype. Neurology. 2000 Jun 13;54(11):2150-3.

2000 -- Pubmed # 10873105 -- Prescott DM, Charles HC, Poulson JM, Page RL, Thrall DE, Vujaskovic Z, Dewhirst MW. The relationship between intracellular and extracellular pH in spontaneous canine tumors. Clin Cancer Res. 2000 Jun;6(6):2501-5.

2000 -- Pubmed # 10656391 -- Vujaskovic Z, Poulson JM, Gaskin AA, Thrall DE, Page RL, Charles HC, MacFall JR, Brizel DM, Meyer RE, Prescott DM, Samulski TV, Dewhirst MW. Temperature-dependent changes in physiologic parameters of spontaneous canine soft tissue sarcomas after combined radiotherapy and hyperthermia treatment. Int J Radiat Oncol Biol Phys. 2000 Jan 1;46(1):179-85.

2000 -- Pubmed # 11261801 -- Chen JG, Charles HC, Barboriak DP, Doraiswamy PM. Magnetic resonance spectroscopy in Alzheimer's disease: focus on N-acetylaspartate. Acta Neurol Scand Suppl. 2000;176:20-6.

1999 -- Pubmed # 10511156 -- McAdams HP, Palmer SM, Donnelly LF, Charles HC, Tapson VF, MacFall JR. Hyperpolarized 3He-enhanced MR imaging of lung transplant recipients: preliminary results. AJR Am J Roentgenol. 1999 Oct;173(4):955-9.

1999 -- Pubmed # 10478261 -- Donnelly LF, MacFall JR, McAdams HP, Majure JM, Smith J, Frush DP, Bogonad P, Charles HC, Ravin CE. Cystic fibrosis: combined hyperpolarized 3He-enhanced and conventional proton MR imaging in the lung--preliminary observations. Radiology. 1999 Sep;212(3):885-9.

1998 -- Pubmed # 9531365 -- Carter DL, MacFall JR, Clegg ST, Wan X, Prescott DM, Charles HC, Samulski TV. Magnetic resonance thermometry during hyperthermia for human high-grade sarcoma. Int J Radiat Oncol Biol Phys. 1998 Mar 1;40(4):815-22.

1998 -- Pubmed # 9853445 -- Doraiswamy PM, Charles HC, Krishnan KR. Prediction of cognitive decline in early Alzheimer's disease. Lancet. 1998 Nov 21;352(9141):1678.

1998 -- Pubmed # 9870205 -- Van Hove JL, Lazeyras F, Zeisel SH, Bottiglieri T, Hyland K, Charles HC, Gray L, Jaeken J, Kahler SG. One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels. J Inherit Metab Dis. 1998 Dec;21(8):799-811.

1998 -- Pubmed # 9754452 -- Lazeyras F, Charles HC, Tupler LA, Erickson R, Boyko OB, Krishnan KR. Metabolic brain mapping in Alzheimer's disease using proton magnetic resonance spectroscopy. Psychiatry Res. 1998 May 20;82(2):95-106.

1997 -- Dewhirst MW, Prosnitz L, Thrall D, Prescott D, Clegg S, Charles HC, MacFall J, Rosner G, Samulski T, Gillette E, LaRue S: Hyperthermic treatment of malignant diseases: current status and a view toward the future. Semin Oncol 1997(Dec); 24 (6):616-

1994 -- Sostman HD, Prescott D, Dewhirst MW, Dodge R, Thrall D, Page RL, Tucker JA, Harrelson J, Leopold KA, Oleson JR, Charles HC, et al: MRI/MRS for Prognostic Evaluation and Therapy Monitoring in Soft Tissue Sarcomas. Radiology 1994;190:269-276.

1994 -- Charles HC, Lazeyras F, Krishnan R, et al: Brain Choline in Depression: In Vivo Detection of Potential Pharmacodynamic Effects of Antidepressant Therapy Using Hydrogen Localized Spectroscopy.Prog Neuro-Psych Biol Psych 1994 (Oct); 18:1121-1127.

1993 -- Davidson JR, Krishnan KR, Charles HC, Boyko O, Potts NL, Ford SM, Patterson L: Magnetic Resonance Spectroscopy in Social Phobia: Preliminary Findings. J Clin Psychia 1993;54:19-25.

1993 -- Prescott D, Charles HC, Sostman HD, et al: Manipulation of Intracellular and Extracellular pH in Spontaneous Canine Tumors by Use of Hyperglycemia. Int J Hyperthermia 1993;9(5):745-754.

1993 -- Krishnan KR, Boyko O, McDonald WM, Charles HC, et al: Magnetic Resonance Morphometry: Image-Analysis Methodology Development for Affective Disorder. Depression 1993;1:159-171.