Daniel Kelly Benjamin, M.D., Ph.D., M.P.H.

Chief, Division of Quantitative Sciences, Pediatrics

Associate Professor of Pediatrics

Department:
Pediatrics

Division:
Infectious Diseases

Email:
dannybenjamindukeedu

Mailing Address:
Box 3499 Medical Center
Durham, NC 27710

Telephone:
919-668-7081

Training:
M.D., University of Virginia School of MedicinePh.D., University of North Carolina at Chapel HillM.P.H., University of North Carolina at Chapel Hill

Last Updated:
September 07, 2009

Clinical Interests:
Infections in the neonate, meningitis, infections in the bone marrow transplantpatient, use of diagnostic tests

Research Interests:
Neonatal Infectious Disease:
1) Neonatal candidiasis including diagnosis, prevention, and therapy
3) Antibiotic and antifungal dosing in neonates, young infants, and children
3) Diagnosis of neonatal meningitis. This is a collaborative study with a large private practice group

Pediatric therapeutics:
1) Global drug development
2) PK-PD, dosing, and safety outcomes in children
3) Data transparency

Publications:
2009 -- Pubmed # 19319022 -- Smith PB, Walsh TJ, Hope W, Arrieta A, Takada A, Kovanda LL, Kearns GL, Kaufman D, Sawamoto T, Buell DN, Benjamin DK Jr. Pharmacokinetics of an elevated dosage of micafungin in premature neonates. Pediatr Infect Dis J. 2009 May;28(5):412-5.

2009 -- Pubmed # 19191635 -- Pappas PG, Kauffman CA, Andes D, Benjamin DK Jr, Calandra TF, Edwards JE Jr, Filler SG, Fisher JF, Kullberg BJ, Ostrosky-Zeichner L, Reboli AC, Rex JH, Walsh TJ, Sobel JD, . Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis. 2009 Mar 1;48(5):503-35.

2009 -- Pubmed # 19117861 -- Cotten CM, Taylor S, Stoll B, Goldberg RN, Hansen NI, Sánchez PJ, Ambalavanan N, Benjamin DK Jr, . Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics. 2009 Jan;123(1):58-66.

2009 -- Pubmed # 19593252 -- Wade KC, Benjamin DK Jr, Kaufman DA, Ward RM, Smith PB, Jayaraman B, Adamson PC, Gastonguay MR, Barrett JS. Fluconazole dosing for the prevention or treatment of invasive candidiasis in young infants. Pediatr Infect Dis J. 2009 Aug;28(8):717-23.

2008 -- Pubmed # 18309318 -- Cohen-Wolkowiez M, Smith PB, Benjamin DK Jr, Fowler VG Jr, Wade KC. Daptomycin use in infants: report of two cases with peak and trough drug concentrations. J Perinatol. 2008 Mar;28(3):233-4.

2008 -- Pubmed # 18171300 -- Hope WW, Mickiene D, Petraitis V, Petraitiene R, Kelaher AM, Hughes JE, Cotton MP, Bacher J, Keirns JJ, Buell D, Heresi G, Benjamin DK Jr, Groll AH, Drusano GL, Walsh TJ. The pharmacokinetics and pharmacodynamics of micafungin in experimental hematogenous Candida meningoencephalitis: implications for echinocandin therapy in neonates. J Infect Dis. 2008 Jan 1;197(1):163-71.

2008 -- Pubmed # 18285612 -- Smith PB, Li JS, Murphy MD, Califf RM, Benjamin DK Jr. Safety of placebo controls in pediatric hypertension trials. Hypertension. 2008 Apr;51(4):829-33.

2008 -- Pubmed # 18283504 -- Baddley JW, Benjamin DK Jr, Patel M, Miró J, Athan E, Barsic B, Bouza E, Clara L, Elliott T, Kanafani Z, Klein J, Lerakis S, Levine D, Spelman D, Rubinstein E, Tornos P, Morris AJ, Pappas P, Fowler VG Jr, Chu VH, Cabell C, . Candida infective endocarditis. Eur J Clin Microbiol Infect Dis. 2008 Feb 19.

2008 -- Pubmed # 18332283 -- Benjamin DK Jr, Smith PB, Jadhav P, Gobburu JV, Murphy MD, Hasselblad V, Baker-Smith C, Califf RM, Li JS. Pediatric antihypertensive trial failures: analysis of end points and dose range. Hypertension. 2008 Apr;51(4):834-40.

2008 -- Pubmed # 18809946 -- Wade KC, Wu D, Kaufman DA, Ward RM, Benjamin DK Jr, Sullivan JE, Ramey N, Jayaraman B, Hoppu K, Adamson PC, Gastonguay MR, Barrett JS, . Population pharmacokinetics of fluconazole in young infants. Antimicrob Agents Chemother. 2008 Nov;52(11):4043-9.

2008 -- Pubmed # 18726835 -- Smith PB, Garges HP, Cotton CM, Walsh TJ, Clark RH, Benjamin DK Jr. Meningitis in preterm neonates: importance of cerebrospinal fluid parameters. Am J Perinatol. 2008 Aug;25(7):421-6.

2008 -- Pubmed # 18989240 -- Greenberg RG, Smith PB, Cotten CM, Moody MA, Clark RH, Benjamin DK Jr. Traumatic lumbar punctures in neonates: test performance of the cerebrospinal fluid white blood cell count. Pediatr Infect Dis J. 2008 Dec;27(12):1047-51.

2007 -- Pubmed # 17484214 -- Smith PB, Morgan J, Benjamin JD, Fridkin SK, Sanza LT, Harrison LH, Sofair AN, Huie-White S, Benjamin DK Jr. Excess costs of hospital care associated with neonatal candidemia. Pediatr Infect Dis J. 2007 Mar;26(3):197-200.

2007 -- Pubmed # 17918526 -- Lenfestey RW, Smith PB, Moody MA, Clark RH, Cotten CM, Seed PC, Benjamin DK Jr. Predictive value of cerebrospinal fluid parameters in neonates with intraventricular drainage devices. J Neurosurg. 2007 Sep;107(3 Suppl):209-12.

2007 -- Pubmed # 18043460 -- Cohen-Wolkowiez M, Benjamin DK Jr, Fowler VG Jr, Wade KC, Alexander BD, Worley G, Goldstein RF, Smith PB. Mortality and neurodevelopmental outcome after Staphylococcus aureus bacteremia in infants. Pediatr Infect Dis J. 2007 Dec;26(12):1159-61.

2007 -- Pubmed # 17284698 -- Li JS, Eisenstein EL, Grabowski HG, Reid ED, Mangum B, Schulman KA, Goldsmith JV, Murphy MD, Califf RM, Benjamin DK Jr. Economic return of clinical trials performed under the pediatric exclusivity program. JAMA. 2007 Feb 7;297(5):480-8.

2007 -- Pubmed # 17080094 -- Cohen-Wolkowiez M, Smith PB, Mangum B, Steinbach WJ, Alexander BD, Cotten CM, Clark RH, Walsh TJ, Benjamin DK Jr. Neonatal Candida meningitis: significance of cerebrospinal fluid parameters and blood cultures. J Perinatol. 2007 Feb;27(2):97-100.

2007 -- Pubmed # 17262048 -- Smith PB, Steinbach WJ, Cotten CM, Schell WA, Perfect JR, Walsh TJ, Benjamin DK Jr. Caspofungin for the treatment of azole resistant candidemia in a premature infant. J Perinatol. 2007 Feb;27(2):127-9.

2006 -- Pubmed # 16968851 -- Benjamin DK Jr, Smith PB, Murphy MD, Roberts R, Mathis L, Avant D, Califf RM, Li JS. Peer-reviewed publication of clinical trials completed for pediatric exclusivity. JAMA. 2006 Sep 13;296(10):1266-73.

2006 -- Pubmed # 16396864 -- Benjamin DK Jr, Stoll BJ, Fanaroff AA, McDonald SA, Oh W, Higgins RD, Duara S, Poole K, Laptook A, Goldberg R, . Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. Pediatrics. 2006 Jan;117(1):84-92.

2006 -- Pubmed # 16882828 -- Cotten CM, McDonald S, Stoll B, Goldberg RN, Poole K, Benjamin DK Jr, . The association of third-generation cephalosporin use and invasive candidiasis in extremely low birth-weight infants. Pediatrics. 2006 Aug;118(2):717-22.

2006 -- Pubmed # 16598296 -- Benjamin DK, Schelonka R, White R, Holley HP, Bifano E, Cummings J, Adcock K, Kaufman D, Puppala B, Riedel P, Hall B, White J, Cotton CM, . A blinded, randomized, multicenter study of an intravenous Staphylococcus aureus immune globulin. J Perinatol. 2006 May;26(5):290-5.

2006 -- Pubmed # 16585303 -- Garges HP, Moody MA, Cotten CM, Smith PB, Tiffany KF, Lenfestey R, Li JS, Fowler VG Jr, Benjamin DK Jr. Neonatal meningitis: what is the correlation among cerebrospinal fluid cultures, blood cultures, and cerebrospinal fluid parameters? Pediatrics. 2006 Apr;117(4):1094-100.

2006 -- Pubmed # 16436720 -- Benjamin DK Jr, Driscoll T, Seibel NL, Gonzalez CE, Roden MM, Kilaru R, Clark K, Dowell JA, Schranz J, Walsh TJ. Safety and pharmacokinetics of intravenous anidulafungin in children with neutropenia at high risk for invasive fungal infections. Antimicrob Agents Chemother. 2006 Feb;50(2):632-8.

2004 -- Pubmed # 14985773 -- Benjamin DK Jr, DeLong ER, Cotten CM, Garges HP, Clark RH. Postconception age and other risk factors associated with mortality following Gram-negative rod bacteremia. J Perinatol. 2004 Mar;24(3):169-74.

2004 -- Pubmed # 14985775 -- Benjamin DK, DeLong E, Cotten CM, Garges HP, Steinbach WJ, Clark RH. Mortality following blood culture in premature infants: increased with Gram-negative bacteremia and candidemia, but not Gram-positive bacteremia. J Perinatol. 2004 Mar;24(3):175-80.

2004 -- Pubmed # 15605069 -- Tiffany KF, Benjamin DK, Palasanthiran P, O'donnell K, Gutman LT. Improved Neurodevelopmental Outcomes following Long-Term High-Dose Oral Acyclovir Therapy in Infants with Central Nervous System and Disseminated Herpes Simplex Disease. J Perinatol. 2004 Dec 16.

2003 -- Pubmed # 12949281 -- Benjamin DK Jr, DeLong ER, Steinbach WJ, Cotton CM, Walsh TJ, Clark RH. Empirical therapy for neonatal candidemia in very low birth weight infants. Pediatrics. 2003 Sep;112(3 Pt 1):543-7.

2003 -- Pubmed # 12949295 -- Benjamin DK Jr, Poole C, Steinbach WJ, Rowen JL, Walsh TJ. Neonatal candidemia and end-organ damage: a critical appraisal of the literature using meta-analytic techniques. Pediatrics. 2003 Sep;112(3 Pt 1):634-40.

2001 -- Pubmed # 11389242 -- Benjamin DK Jr, Miller W, Garges H, Benjamin DK, McKinney RE Jr, Cotton M, Fisher RG, Alexander KA. Bacteremia, central catheters, and neonates: when to pull the line. Pediatrics. 2001 Jun;107(6):1272-6.

2000 -- Pubmed # 11015513 -- Benjamin DK Jr, Ross K, McKinney RE Jr, Benjamin DK, Auten R, Fisher RG. When to suspect fungal infection in neonates: A clinical comparison of Candida albicans and Candida parapsilosis fungemia with coagulase-negative staphylococcal bacteremia. Pediatrics. 2000 Oct;106(4):712-8.