Allison Elizabeth Ashley-Koch, Ph.D.

Associate Professor of Medicine

Department:
Medicine

Division:
Section of Medical Genetics

Email:
aakochchgduhsdukeedu

Mailing Address:
Box 3445, DUMC
Durham, NC 27710

Telephone:
919-684-2702

Training:
Ph.D., Emory University

Last Updated:
June 10, 2008

Research Interests:
My primary research interests are in the genetic basis of psychiatric and neurological disorders.  I am currently involved in studies to dissect the etiology of attention deficit hyperactivity disorder (ADHD), autism, essential tremor, familial spastic paraplegia, and trichotillomania.  Additional interests include genetic modifiers of mendelian disorders, particularly the identification of loci influencing disease severity in sickle cell disease.

Publications:
2006 -- Pubmed # 17003809 -- Zuchner S, Cuccaro ML, Tran-Viet KN, Cope H, Krishnan RR, Pericak-Vance MA, Wright HH, Ashley-Koch A. SLITRK1 mutations in trichotillomania. Mol Psychiatry. 2006 Oct;11(10):887-9.

2006 -- Pubmed # 16674551 -- Ashley-Koch AE, Mei H, Jaworski J, Ma DQ, Ritchie MD, Menold MM, Delong GR, Abramson RK, Wright HH, Hussman JP, Cuccaro ML, Gilbert JR, Martin ER, Pericak-Vance MA. An analysis paradigm for investigating multi-locus effects in complex disease: examination of three GABA receptor subunit genes on 15q11-q13 as risk factors for autistic disorder. Ann Hum Genet. 2006 May;70(Pt 3):281-92.

2002 -- Pubmed # 12355402 -- Reid E, Kloos M, Ashley-Koch A, Hughes L, Bevan S, Svenson IK, Graham FL, Gaskell PC, Dearlove A, Pericak-Vance MA, Rubinsztein DC, Marchuk DA. A Kinesin Heavy Chain (KIF5A) Mutation in Hereditary Spastic Paraplegia (SPG10). Am J Hum Genet. 2002 Nov;71(5):1189-94.

2001 -- Pubmed # 11354831 -- Ashley-Koch A, Bonner ER, Gaskell PC, West SG, Tim R, Wolpert CM, Jones R, Farrell CD, Nance M, Svenson IK, Marchuk DA, Boustany RM, Vance JM, Scott WK, Pericak-Vance MA. Fine mapping and genetic heterogeneity in the pure form of autosomal dominant familial spastic paraplegia. Neurogenetics. 2001 Mar;3(2):91-7.

1999 -- Pubmed # 10552924 -- Ashley-Koch A, Wolpert CM, Menold MM, Zaeem L, Basu S, Donnelly SL, Ravan SA, Powell CM, Qumsiyeh MB, Aylsworth AS, Vance JM, Gilbert JR, Wright HH, Abramson RK, DeLong GR, Cuccaro ML, Pericak-Vance MA. Genetic studies of autistic disorder and chromosome 7. Genomics. 1999 Nov 1;61(3):227-36.

1998 -- Pubmed # 9718348 -- Ashley-Koch AE, Robinson H, Glicksman AE, Nolin SL, Schwartz CE, Brown WT, Turner G, Sherman SL. Examination of factors associated with instability of the FMR1 CGG repeat. Am J Hum Genet. 1998 Sep;63(3):776-85.